Ok so the Presonus soundcard is multi-client. I removed the M-Audio and installed it and instantly both worked together very nicely. The only problem I have now is that when I flip over to MIR while doing a playback, Studio One stops playing until I click back to Studio One. I have set it up to release the sound driver in the background but this had no effect on it stopping playback when in the background. This is obviously not a VSL issue. I have a support call into Presonus on how to get playback to continue while in the background.
Thanks for all the help and immediate responses.
Maestro2be