You're more than welcome. FW800 has plenty of bandwidth for what I'm asking of that machine; again, it's the drive latency (seek time) that's more important. I wouldn't run my main machine off FW800, but for a slave it's fine. Also, the libraries are spread across 3 drives on the slave (strings/winds/brass/perc), so that helps too. I would definitely NOT use the internal drive for samples.
The iMac only has 8 GB RAM in it right now, but that's adequate; the G5 it replaced only had 8 GB as well, and for what I'm asking of it, that's fine. I'm running all the keyswitch patches of every solo & string group from EW Platinum, which pretty much covers every string articulation in that whole library. I'm also running most of the Platinum wind articulations as well plus all the special effects, runs, grace notes, etc. Then from Epic Horns I have all the commonly used stuff (sustains, staccatos, schmett, slow/fast legatos, glisses, etc.) and finally, all the big drums & ethnic perc from Storm Drum 1. Total is 80 instruments loaded at once (sorry, I was wrong in my earlier post) - 16 x 5 Kontakt instances.
As of Kontakt 4.1 and the new rapid load feature (forget the term they use), it loads AMAZINGLY fast. The entire 80 instruments (saved as a single VE Pro "metaframe" on the iMac) loads in less than a minute. On the G5 I think it took 9 minutes, so I'd call that an improvement! My main Mac runs ~225 more Kontakt, VSL & EW PLAY instruments, and that whole template loads in around 1.5 minutes. I also run the majority of LA Scoring Strings on my other slave - a MacBook Pro. It all works incredibly well, except for a few minor issues with VE Pro & Logic (to do with latency compensation when bouncing) - but those are easily worked around.
I absolutely LOVE this setup, and it has fundamentally improved my workflow!
Hope that helps,