Good question, William.
The main difference is that we have much fewer options to change the sonic signature of a convolution-based reverb than with the "classic", synthetic reverbs we are used to - unless someone takes the step to manipulate the IR _itself_. This can lead to some major brain surgery :-] if you know what to do, or you make things simply worse in case you don't. All the Sampling Reverbs I know, no matter if they are hard- or software-based, offer just a few basic parameters to tweak, like IR-length, pre-delay, some more or less sophisticated ways to change the envelope of the IR, basic EQ and/or filters, and maybe stereo-width.
With synthetic reverb, you have a myriad of options, down to the position, the level and the timing of a single early reflection (out of 1024 or so ... 8-] ...). This is great, and a big problem at the same time, because you have to know pretty well what you're after - and how to achieve it.
This means: yes, it's mainly a question of choosing the right set of IRs, and a more or less intuitive adaption of the few aspects of their sounds I mentioned above. While this leads to a behaviour I call "preset zapping" (something I actually hate, wearing my sound-engineer's hat), it is actually a very easy and conclusive way to find the room I like (... from the perspective of the musical half of my ego).
The mix between dry and wet levels is _very_ specific and depends on completely un-scientific aspects like personal taste, the mood and the arrangement of the piece I'm working on, as well as on the source and the quality of the IRs used, of course. But in general I'd say that I use more of the wet signal in my mixes when I use Sampled Reverb - simply because there's no reason to hide its deficiencies (as it is the case with synthetic reverb, most of the time).
****
I like this thread! :-]
/Dietz - Vienna Symphonic Library