You say your loading time for that template is 35 to 40 minutes - please tell us you're not loading from a spinner drive but an ssd. Or multiple ssd's. If you're on a Mac Pro cheesegrater putting those ssd's in a pcie card adapter will double the loading speed from if they're in the drive bays.
Oh yes multiple ssds of course, and on a PC with double xeon.... Just lots of instruments i guess, and it loads up into about 240gb of ram . I know a couple of fellow composers who have the same "problem", so its normal for a template that size
Where are those ssd's - inside the computer or outside? If outside how are they connected? You do have Kontakt Memory Server disabled right? With that amount of memory (never heard of a machine having that much ram) it sounds like you're having everything load into ram instead of streaming from the ssd's. If so here's a hint - let things stream.