Yes, MS... this is true. As I replied there, the only issue is an incorrect reference to the right executable file in the regedit.
So if your system is NOT 64bit, the regedit association refers anyway to the "Vienna Ensemble Pro x64.exe" file, which, obviously is not installed in a 32 bit system. This wrong link doesn't allow to open a .mframe file by double clicking on it or by putting it on the Startup folder (again, this issue only affects 32 bit systems).