Jerome, using different IAC busses ensures there are no mix-ups - you just select a different "MIDI interface."
What I haven't experiemented with is how to separate the audio outputs from each instance. The Vienna Instruments player allows you to select one device, e.g. RME Fireface or MOTU PCI-424 or built-in; there doesn't seem to be any way to be any more specific than that. I assume Soundflower is just another device, and it'll have the same problem.
So the first instance is no problem, because it's going to go to the default output pair for the audio driver. And you can of course route the outputs inside any host to a separate pair; so far so good. But when you add the second insetance outside the host, that's when I think you might have to do some thinking.
What I haven't experiemented with is how to separate the audio outputs from each instance. The Vienna Instruments player allows you to select one device, e.g. RME Fireface or MOTU PCI-424 or built-in; there doesn't seem to be any way to be any more specific than that. I assume Soundflower is just another device, and it'll have the same problem.
So the first instance is no problem, because it's going to go to the default output pair for the audio driver. And you can of course route the outputs inside any host to a separate pair; so far so good. But when you add the second insetance outside the host, that's when I think you might have to do some thinking.