as far as colorization, i can't really say for sure. mixes are translating well though so i imagine its minimal if anything. perhaps someone else could provide more info, if not here, over at osxaudio.com or unicornation.com.
one thing to bear in mind is that there are three sections to the 2408 such that if one is used for analog i/o, it is lost to lightpipe. in other words you could have either three lightpipe feeds, or two lightpipes and one analog, but not both at the same time. kind of sucks but it is easy to switch it (in software thru a thing motu calls the pci audio console) if that works for you.
one thing to bear in mind is that there are three sections to the 2408 such that if one is used for analog i/o, it is lost to lightpipe. in other words you could have either three lightpipe feeds, or two lightpipes and one analog, but not both at the same time. kind of sucks but it is easy to switch it (in software thru a thing motu calls the pci audio console) if that works for you.