It would really all depend on your work flow. If you know for a fact that you're finished with a track, you could unload some of the samples. This would give you some head room to add more instruments if you need them.
It doesn't benefit during the 'making' stage or if you come back and need to add a part to a track, as you'll just have to reload everything.
It doesn't benefit during the 'making' stage or if you come back and need to add a part to a track, as you'll just have to reload everything.