Those cathedral settings are simply awe inspiring.
For actual mixing work I strongly suggest to stick to the scene "Analytic Dry" (or "Analytic Position), though, with Ambience and Focus left untouched at default center position. 😊
My understand is/was that another other than "analytic Dry" or "analytic position" configurations in dearVRmonitor are meant mainly to attempt to recreate what would happen to our mix if were actually playing it back on a 7.1.2 loudspeaker system in that environment. So my thoughts are that the dry analytic configurations give us the purest ability to position our instruments and really setup our mix exactly as we want it to sound..hearing very purely the MirPro3D imaging... especially through headphones. This would also be a pretty close estimate of what would be heard if streamed as Dolby Atmos from Apple Music (into headphones)..
However, once we are getting to later stages it can also make sense to monitor through, for example, the home-theater configuration...or perhaps cinema configuration, etc. such that we can still verify that it has not become too reverby when played back for real, in a room that has its own echos also happening.
Some of the other larger venues provided by dearVRmonitor are interesting and may sound nice, but have little usefulness in my mind. I mean yes you could bounce a final binaural rendition that has dearVR's room ambiences burned into the binaural result, but how are you going to distribute that? I think mainly the dearVR ambiences should be thought of as available "monitoring environments". Its an attempt to emulate what would happen if your final mix were played back over loudspeakers in that environment...adding more acoustics.
I think its unlikely that anyone will ever be playing my symphony #1 over a 7.1.2 loudspeaker system in the middle of a cathedral. See what I mean? Use MirPro3D and/or additional FX to make it sound as you want..using the analytic modes for setting up your stage and sounding great, use legitimate target playback environments in order to verify the mix, if its going to be played back in those environments, did not become too much reverb wash., and realistically consider which of those environments even make sense for that.