Just installed the upgrade to VEP 6 on my Mac (Yosemite) today and aside from a couple of stops during the plugin scan, and the scaling issue (not exactly a big deal IMHO) it seems to be behaving in regular Pro Tools 12.5.1, Reaper 5.22 and Ableton 9.6.2.
On my install, I found that VEP was stumbling on several Waves demos that are no longer authorized. So, if you're lazy like me, this might be a good reason to finally get in there and delete those dead demos from your plugins folders.