One has to realize that using samples involves bypassing everything that performers do.
The sample user has to become a conductor, but even more - he has to become a player to a certain extent. Conductors actually have it much easier than the sample user. They can stand in front of a great orchestra, wave their arms, and beautiful sound comes out.
With samples, you don't have that luxury - you have to work harder. Because you are doing a lot of what the players do, with expression, and what the conductor does, with controlling all the elements of the perfomance. So there is no easy solution - it is pure musical work, figuring out what sounds best on each line of your composition.