Of course:
Windows 7 64 bit
Dedicated DAW PC, no antivirus installed
Cubase 6.05 64bit
Motherboard: Asus P6T
RAM: 12GB DDR3
CPU: i7930
Hard drives: 500GB 7200rpm system hard drive, 3x1.5 TB 7200rpm hard drives. Vienna Sample Library is installed in one of the 1.5 TB hard drives with 64MB cache.
Video Card: Asus 9400 GT Silent
Audio interface: RME UFX, latest software (but same problem used to happen with RME Multiface and TC Electronic Impact Twin).
I have to mention, that I used to have the same problem on a Toshiba Windows laptop running Windows XP in the past.
It is very peculiar because, after 2-10 minutes pass, everything runs smoothly. Apart from that, if I close Cubase , restart it and use VIP again, the spikes do not appear. Same when I run in standalone. If I run VIP , close it, open it again, the spikes do not appear. It's just the very first time that I load an instance that these problems happen. And it happens even with one single instance, there is no difference if I add 1 instance or 100. Even if I have 50 VIP in some projects (sometimes I do), after 2-10 minutes everything runs smoothly.
Another thing to note is that when the spikes happen, Windows Task manager shows nothing wrong, and DPC latency checker reports perfectly normal values like nothing happened.
Hope that helps, if you need more info, I will be glad to provide you with it.