Dietz, it seems good to respond to your last comment, although if you would like more detail, please feel free to PM me, and I would be happy to respond.
The one control that could give me some real difficulty is the MIR Control Icon. However, since sliders are available as alternate controls, that would serve as a good workaround if needed (note that I read things by getting my nose up to the screen, concentrating on small areas, and using as large a screen image as possible).
One of the things I most appreciate about VSL's interface designs, is that instead of going for "eye-candy" you choose clean fonts and layouts. While I find nothing (by anyone) to be "easy", VSL color schemes and designs actually do work for me. The large sans serif fonts of the VI instrument pages are excellent, and as a result, combinations that often cause me trouble are at least ok. Even the small fonts (that really are difficult) are at least cleanly designed, and that is a significant help. Interestingly, the color scheme of the old VE 2 mixer page is as close to ideal as I have ever found for my sight issues - clean light colored fonts on a black background. The fact that you almost always use light fonts on dark backgrounds really helps.
At least for my own visual impairment (and this probably can be generalized for other types of visual impairments), the design choices outlined above truly help. Poor font size, poor font design, and poor contrast are often main obstacles when trying to use any software in conjunction with a visual impairment.
By contrast, the font choice and overall GUI design of the new player for your most often mentioned main rival will strain my eyes out completely within about three or four minutes. Also, in general, too much information, displayed in too small an area (even if clean fonts are used) can cause problems.
I hope you find these comments to be of some constructive use.