The tuning dilema is well illustrated in preformance of Vln and Piano duos in pre atonal music. The Violinist instinctivly plays true 5th, leading tone 3-4 cents higher than a major 3rd, etc, while the pianist of course can't, so the two are never really in tune like a string quartet would be. Personally my head hurts after 15 min of duos or trios with piano.

Indeed, but it could happen that with such words we provoke all piano players. In earnest: Listening to such music can cause head hurts or not, depending of the personal musical experience. Making such music with a string or a wind instrument in common with a piano is gruelling.