Before considering running multiple VE Standalones you need to have hardware that will support doing this. In my experience, for example, with a dual 2.5GHz G5, I ran out of CPU power before running out of RAM. Using multiple standalones should work much better on an 8 processor MacPro.
To run multiple VE standalones:
1. Duplicate the VE application in the finder (select the VE application, then choose "duplicate" - - or use the keyboard command "command-d")
2. Rename the duplicated application.
3. Open the original application, then open the renamed duplicate application.
In its current iteration you can, according to VSL Support, open 3 standalone instances of VE 2.
For the MIDI input of the standalones, open AudioMIDI Setup (found in the Utilities folder) click on te MIDI Tab if it is not already selected, Double click on the IAC driver, a dialog box will open make sure that "Device is Online" is checked. Click on the "Ports Tab" and create as many IAC busses as you will need (presumably 3).
Assign MIDI input on the first instrument in the first standalone to IAC Bus 1 and Channel 1. As you add instruments to the standalone they will, the latest version of VE 2, automatically get assigned in sequence if the preceding instrument is selected. (If Instrument 1 is selected then when you click Insert Instrument, Instrument 2 will be assigned to IAC Bus 1/Channel 2.)
Audio routing back into the DAW is accomplished either by hardware connection as I described earlier or, if you are using and RME or Apogee Symphony card based audio interface, with the software that accompanies those interfaces. (the Apogee Ensemble and Duet do not allow software routing.) There are also two 3rd party applications that are intended for this purpose.
Soundflower (made by Cycling 74) - - which, in my experience, was unusable because of frequent digital artifacts (clicks and pops) during playback.
JackOSX - - some people have reported success with this, but I have never gotten it to work - - no doubt it is my own fault, but I found the software interface not particularly intuitive.