@Nick Batzdorf said:
It's a pain to start them all up - although there's probably a way to record a macro to do that - but after that they're all started and you don't have to reload them every time you start a new cue. And of course you're getting more mileage out of a single Mac than anyone has got out of any machine before.
Not to go OT-- but you can at least set your Startup Items in System Prefs in OSX. If your host can be set to autoload your project, all you need to do is log out and log back in. Upon boot, everything will load without thinking about it
http://docs.info.apple.com/article.html?artnum=106146
A macro would offer greater flexibility. I was able to do this when I used the driver for a programmable Kensington mouse, but I've not tried to macro-start in OSX.