Hello Tom
I'm a long-time Nuendo/Cubase user, and have been with VSL from First through Pro and now Synphonic Cube. However, I am on the PC platform for all of these. In that Nuendo/Cubase & VSL are cross-platform, I can tell you that I have been happy with Nuendo as my main DAW.
Yes, it has audio and midi sequencing to a high specification. Currently, I run Nuendo on 1 PC, and use two slaves running either V-Stack [from steinberg] or Cubase [which I also have] as VST wrappers for VSL on the slaves.
You should check out the Nuendo forums at
http://forum.nuendo.com, and you'll get a feel for where its at, and what are some of the current issues with the software.
One huge difference between Steinberg and VSL, I would have to say, is in the online support area. Frankly, it is scant from Steinberg, in comparison to a very fast and helpful service here at VSL. [In dealing with a few online support facilities over the years, VSL are the exception rather than the rule, so Steinberg are no worse than average, I suppose, in that regard]
Although not as popular worldwide as PT, Nuendo/Cubase would run second in the popularity stakes, I would think.
As to whether you would need Nuendo moreso than Cubase, if what you're at is sequencing midi and audio, Cubase would do the job. If video also is a requirement, I would lean towards Nuendo.
If you have any other specific questions, I'd be glad to answer if I can
All the best
Andy O'Callaghan
Sutton Sound Ltd.
Dublin 13