Ok, I've done a clean install of the latest nvidia drivers, but it did not help.
One more note to the grid/hotspots issue. When I load up a metaframe the "grid" and "hotspots" does not respond. The grid shows, but cannot be turned off. The "Hotspots" overlay does not show and does not resond to the button.
Now, on a test metaframe I have 2 instances of VE Pro with 5 instances of VI Pro 2 each. In the first VE Pro instance, If I click all 5 VIs, no matter which order, each label will turn white. When going from one instance to the next, the unselected instance does not revert to blue. When I have clicked all 5 instances the "hotspots" overlay and "grid" suddenly will work. So if I have activated the "Hotspots" button, the lit-up overlay will not show UNTIL I click the final fifth (1 through 5) instance of VI Pro. The label issue, however, still is there - all instances will be white.
Also, when clicking the first instance of VI Pro (the icon representation inside MIR), the corresponding label of VI Pro in the channel rack to the left, will turn white. Now this label, whichever instance I click first, will stay white until I have clicked through all 5 instances. This means that in the channel rack, the first VI label will stay white, indicated that it is selected, even though another instance is selected. So until I've clicked through all instances, the channel rack indicates that two instances are selected. But it seems this is just a graphical glitch because, there are no group selection active. For example, I cannot move both instances simultainiously.
This is the same for each VE Pro instance which is hosted in the metaframe. Also as I've mentioned earlier, when creating a new VE Pro instance, either inside this test metaframe or a new metaframe, none of this issues are present. It is when the metaframe is reloaded the problems occur.
-tom