Hi Mike and Jonathan,
Well, I've made a few decisions and bought some stuff already, and I'm pretty sure of what I'll buy to complete things. Again, I'm going to try to do everything with a single 12 core machine, but I'm leaving open the option of a second machine (perhaps splitting some of the things I'm buying between them).
I ordered a 12 Core 2.93Ghz Mac (due to arrive on August 30). I ordered it with a single 512GB SSD. That seems to make sense, because from what I've heard, Apple expects things to be restored to factory configuration if you need service. I then bought 48Gb of memory from OWC (six 8 Gb sticks). This will keep me at triple channel, running memory as fast as possible. I also got an OWC Blu-Ray drive for my second optical drive compartment. I bought two 200GB OWC SSD RE drives as work drives (more than enough storage for the amount of projects I like to keep on active drives). The RE drives have the SandForce controller, show lots of writing and rewriting shouldn't degrade their performance over time. I also bought a RocketRAID SATA III 6Gb/s, four port PCIe card (Apple has a competitive price on these). I also bought a four drive SATA 3.0 enclosure.
Now to finish things off, I think I'm going to buy four of the new Crucial SSD SATA III 6Gb/s 256Gb drives. The performance of these seems pretty astounding (355Mb/s). I probably won't RAID them unless I get EW's HS which is 310Gb, and won't fit on a single drive. I'll easily be able to spread my 540Gb of VSL content over these drives. I'll also have room to put some libraries on my system SSD. Finally, in my remaining computer drive slot, I'll either put a 600Gb Velociraptor, or a 2Tb Seagate drive to hold all my additional, not so frequently used libraries.
Anyway, I think this will be good to start, and allow me to do some torture testing to see how things hold up. I'm thinking that Logic doesn't use all the cores, but if I open additional VEPro instances outside of Logic, they will use those cores. Won't they? The other thing I'll undoubtedly need to experiment with is whether to run Logic at 32bit or 64bit. Hopefully, even if I'm running Logic at 32 bit, I can still run instances of VEPro at 64 bits. I guess I'll find out soon enough. ;)
Whether or not I add an additional machine will be determined by how easy it is to swamp this machine, and/or how stable the machine is with lots of stuff running. With SATA III SSDs and 1333 triple channel memory, I'd hope that loading large templates would be a lot faster. We'll see about that, too.
Obviously, the other thing that would entice me to add a second machine would be if VSL comes out with a version of MIR for the Mac (hopefully one that can run audio and MIDI via LAN, with no additional interfaces).
FWIW, my audio interfaces are two Metric Halo ULN-8's (which I have yet to turn on). The ULN-8's have a lot of onboard DSP which will take pressure off the Mac. It's been years now since I've done a major update. Still running my PT Accel HD6 system with four 192 interfaces on a G5 DP 2.5, plus one additional DP G4 and four Pentium 4's in server racks. Antiques!!! All that stuff makes a lot of racket in the machine room, uses lots of electricity and causes my HVAC to run hard during the summer. The quiet of the new system is going to be eerie. I think I'l get used to it pretty fast, though. :) I'm also looking forward to being able to put my whole system to sleep. At the moment, getting my current system turned on, booted up, shells loaded, and content loaded is a major chore.