Many thanks Christian.
I suspect I'll have to go the 2GB module route (6 per processor) in order to minimize cost, and may even have to start with 1 CPU and add the 2nd when prices fall a little. Better that way than have a system with no room for 'growth'.
I'm finding that the 24GB requirement really limits spec options a little. I had an X58 system all ready to go, but I just couldn't find reasonably priced 4GB unbuffered RAM modules, and I didn't fancy maxing it out with 6x2GB modules, and then discovering it wasn't enough. 4GB ECC registered modules are a fraction of the price, meaning you can spec a Xeon system for pretty much the same cost.
I'm hoping 3 1TB drives with the VI's spread across them and a 9500GT should be ok on the HD and graphics front.
Thanks again for your help.
Jules