ok,
What do yo want to to? record , for example, a voice from you mixer? or a midi VST sequence?
The VST instrument, I use Kontakt 2 or EWSO for example, and then I export all as wave.
In the configuration I use adat inputs because the sound come from a yamaha mixer conected to RME with optical conection.
With other programs you can record?, for example Soundforge?
Greetings